Sodium metavanadate exhibits carcinogenic tendencies in vitro in immortalized human bronchial epithelial cells

CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells

Inter-individual variation in CCAAT/enhancer binding protein gamma (CEBPG) transcript expression in normal human bronchial epithelial cells (NBEC) is associated with predisposition to lung cancer. We hypothesize that this inter-individual variation is in part explained by cis-acting genetic variation in CEBPG. To test this hypothesis we measured transcript expression derived from each parental ...

Multipotent Capacity of Immortalized Human Bronchial Epithelial Cells

While the adult murine lung utilizes multiple compartmentally restricted progenitor cells during homeostasis and repair, much less is known about the progenitor cells from the human lung. Translating the murine stem cell model to humans is hindered by anatomical differences between species. Here we show that human bronchial epithelial cells (HBECs) display characteristics of multipotent stem ce...

Cyclin D1 Proteolysis: a Retinoid Chemoprevention Signal in Normal, Immortalized, and Transformed Human Bronchial Epithelial Cells

Background: Retinoids (derivatives of vitamin A) are reported to reduce the occurrence of some second primary cancers, including aerodigestive tract tumors. In contrast, b-carotene does not reduce the occurrence of primary aerodigestive tract cancers. Mechanisms explaining these effective retinoid and ineffective carotenoid chemoprevention results are poorly defined. Recently, the all-trans-ret...

Cytotoxicity of Silver Nanoparticles on Human Gingival Epithelial Cells: An In-Vitro Study

  Objective: Nanosilver has numerous applications in medicine due to its potent antibacterial activity. However, data regarding the bio-safety of its effective concentrations is scarce. This study aims to assess the toxicity of silver nanoparticles on human gingival epithelial cells under in-vitro conditions.   Methods: This in vitro study evaluated the toxic effects of filtered and unfiltered ...

Sildenafil Effect on Nitric Oxide Secretion by Normal Human Endometrial Epithelial Cells Cultured In vitro